In sub-acute toxicity study, total of thirty (30) rats were randomized into six groups of five rats per group: Group 1 served as control and was administered with 1ml of distilled water (dH2O). Article When you boil the plant, it turns the water red. However, the mechanism by which phytochemicals act as prooxidants in-vivo is still under investigation [25]. Elevated activity of catalase in liver and kidney across tested doses of J. carnea ethanol extract showed no significant effect compared to the control. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. Prevent this by spraying the leaves with water. View abstract. The research work was carried out in collaboration between all authors. This is in agreement with previous work on the reversed effect of J. carnea leaf extract on anaemia induced experimental rat [9, 21]. Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. Oyenihi OR, Brooks NL, Oguntibeju OO. This leaf replenishes your blood supply immediately. Ewe eje is an age-old herb medically proven to act as a blood tonic which can be attributed to its nutritional composition. View abstract. Saunders; 1995. p. 26873. Bottom Line. Ewe eje is safe and healthy for consumption. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. In conclusion, oral acute administration of J. carnea ethanol extract is safe because neither mortality nor any signs of toxicity were observed in experimental rats. Ewe eje isnt capable of causing any side or negative effects if consumed moderately. Keep in mind that natural products are not always necessarily safe and dosages can be important. As a consequence, depletion of reduced glutathione (GSH) either by removal from the cell or oxidation to GSSG could eventually lead to mild oxidative stress in cells and tissues [33, 34]. It is cultivated and sold as a decorative potted plant and is planted in landscaping as a feature plant in warm . 2010;4(8):6804 https://doi.org/10.5897/JMPR09.487. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. It also grows in some Caribbean islands, including Trinidad and Tobago . Proximate analysis of the aqueous extract of J. carnea leaves showed that it contains appreciable amounts of 53.07 0.07% carbohydrate, 9.26 0.02% ash, and 26.71 0.02% . This is in agreement with study of Anthonia et al., [21] who obtained LD50 above 5000mg/kg for aqueous extracts of J. carnea leaf. Evid Based Complement Alternat Med. In these groups, from mild to severe order; the renal cortex appears distorted, Renal glomeruli and dillated capsular spaces appeared collapsed with characteristic pyknosis of the mesangial cells, The renal tubules, interstitial spaces, appears distorted with presence of red inflammatory cells, hemorrhagic cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane (red arrows). When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. Treatments of experimental animals were in accordance with the Principle of Laboratory Animal Care manual guide of National Institute of Health [14] as approved by the Institution Research Ethics committee. Deleting this collection CANNOT be undone. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Significant (P<0.05) decrease observed in liver total protein of rat administered with 1200mg/kg of extract could be due to intrinsic factors in-vivo that might not necessarily indicate adverse reaction of the extracts. Be careful about the moisture in the soil, avoiding letting it dry completely. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Rich on haematological and biochemical parameters in healthy Wistar rats. This research focused on the safety and in vivo antioxidant status of healthy albino rats exposed to J. carnea leaf ethanol extract. Ewe eje or ewe ajeri is prepared differently by different folks. https://doi.org/10.1186/s40816-020-00234-4, DOI: https://doi.org/10.1186/s40816-020-00234-4. J Ethnopharmacol 1985;13(1):3-49. Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. Antianaemic potentials of some plant extracts on phenyl hydrazineinduced anemia in rabbits. Part of This suggested that the extract did not alter tissue function in converting harmful hydrogen peroxide to water and oxygen. 1. Mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) showed significant (p<0.05) increased at 50mg/kg while doses greater than 100mg/kg showed no significant difference compared to the control. In a reaction mixture containing 0.01M phosphate buffer (pH7.0), 0.5ml of 0.2M H2O2 and 0.4ml distilled water, 0.5ml of sample was added. Karigidi is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. 1958;25(1):192205. Total reaction mixture of 3ml contained 2.95ml of 0.05M sodium carbonate buffer (pH10.2), 0.02ml tissue sample and 0.03ml of epinephrine (2mM) in 0.005N HCl was used to initiate the reaction. 15 Amazing benefits of brocoli juice and side effects. Studies have shown that ewe eje contains antioxidant and cardio-protective properties. Side effects of Ewe eje (Justicia carnea leaf Side Effects). Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. In this report, MCV, MCH and MCHC in treated group were not altered compared to the control. Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Vitamin C and E are antioxidants. Only plants will be removed from the collection. The cuttings should be placed in individuals pots and put under glass or shaded location, away from direct sunlight. Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. Briefly, 1.0ml of the sample was mixed with 2ml of TCA-TBA-HCl reagent (0.37% thiobarbituric acid, 15% trichloroacetic acid and 0.24N HCl in 1:1:1) and boiled at 100C in a water bath for 15min. They should be watered regularly (once per week), but not overwatered. Over time, they cause atherosclerosis and myocardia infarction. Superoxide dismutase was carried out using the method of Sun and Zigma [18]. https://doi.org/10.1016/j.biocel.2006.07.001. To create additional collections, you must be a paid member of our site. Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. Radhika J, Sathya S, Jothi G, Japasheba JL. 2008; 10:2. Tags: benefits of justicia carnea, health benefit of justicia carnea, justicia carnea . 2005;102(2):197201. The effect of the ethanol extract of Justicea. There are several nutritional benefits of justicia carnea leaves. Nunes TRS, Cordeiro MF, Beserra FG, et al. The absorbance was read at 412nm against the reagent blank. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. The spectacular rosy plumes of the flamingo-colored flower are distinctive and attract hummingbirds to pollinator gardens. Justicia carnea belongs to the family- Acanthaceae. The leaves are rich in carbohydrates and proteins, which are for energy production and maintenance of cellular activities. 2013;3(4):1248 https://doi.org/10.7324/JAPS.2013.3422. Luckily, the unique flowers of Jacobinia carnea and its foliage are free from major pest and disease concerns. What this means is that aside fighting anemia, justicia carnea leaves also improves your cardiovascular health by suppressing the tendency for dyslipidemia. This special leaf can be found around us- in our neighborhood. Histopathological examination of liver and kidney showed mild to severe pathological lesion in a dose dependent manner. J Am Diet Assoc. At the end of 14th day of administration, rats were allowed to fast overnight, sacrificed to collect samples for biochemical analysis and histopathological examination. Anthonia OC, Ikechukwu UR, Uzoma NO, Sunday ELU. Ewe eje is a rich source of phytochemicals, minerals and vitamins. J Acute Disease. Why urban citizens in developing countries use traditional medicines: the case of suriname. ESA conceived and designed the study. 2011;5(9):48992 https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867. Mr. T.S. How often should it be watered? Justicia carnea is amedicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. J Nat Prod 1988;51(3):599-600. A multidisciplinary overview of intoxicating snuff rituals in the western hemisphere. In Nigeria, the leaf of Justicia carnea is usually prepared with edible vegetables to make soup, boiled separately in water to make tea or prepared by cooking with other medicinal plants for therapeutic purposes. The ability of glutathione to regenerate these dietary antioxidants has been linked to the redox state of glutathione disulphide-glutathione couple (GSSG/GSH) ratio [31]. Feed the soil when the cutting is new to encourage better growth. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. J Ethnopharmacol. It also grows in some Caribbean islands, including Trinidad and Tobago. How long does it take for Aju mbaise to work. CAS Safety assessment of Uvaria chamae root extract: acute and subchronic toxicity studies. Justicia carnea is affects Fertility according to a researched article published on ResearchgateJusticia carnea was found to lower sperm count Male Wistar Albino ratsthe effect of this herb on female fertility is not yet known. 2017;16(2):21730 https://doi.org/10.17306/J.AFS.2017.0492. Arch Toxicol. Free radicals and antioxidants in normal physiological functions and human disease. The resultant liquid would turn crimson red. The weight of organs (liver and kidney) reduced steadily in a concentration dependent manner. 2012; 22(1):220238; https://doi.org/10.1590/S0102-695X2011005000196. Join now and start creating your dream garden! Anal Biochem. Justicia carnea, the Brazilian plume flower, Brazilian-plume, flamingo flower, or jacobinia, is a flowering plant in the family Acanthaceae. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Accept Create a membership account to save your garden designs and to view them on any device. These animals were obtained from the animal house of the Department of Chemical Sciences, Ladoke Akintola University of Technology Ogbomoso Oyo State, Nigeria. All authors read and approved the final draft of the manuscript. View abstract. The cuttings are taken from the parent plant in the spring after the plant has bloomed. International Journal of Phytomedicine and Phytotherapy, Clinical Phytoscience The liver and kidney of rats administered with 500mg/kg JCEE and above demonstrated slight increase in MDA level with significant (P<0.05) increase only observed in the liver of rats that received 1200mg/kg of extract. In winter, you might have to spray the leaves with water, especially if the air is dry. The protein content may help in cellular functions and are building blocks for structural and functional biomolecules. The absorbance was taken at interval of 1min for 3min at 480nm. Different researches performed on wistar rats has proven the non toxicity of justicia carnea. Technical guidelines assembly of veterinary medicine research. 1. Correspondence to J. Appl. Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. He has B.Sc.,and M.Sc. 2. Akintimehin, E.S., Karigidi, K.O., Omogunwa, T.S. 400). In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. 1983;53:27589. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). Chanda S, Parekh J, Vaghasiya Y, Dave R, Baravalia Y, Nair R. Medicinal plants - from traditional use to toxicity assessment: a review. In this article i will take you through the nutritional and medicinal benefits of justicia carnea. The flowering Justicia plant is a perennial native to the Atlantic Forest eco-regions in eastern Brazil. The gradual decrease in the weight of organs following short-term exposure of J. carnea leaf ethanol extract may be attributed to adaptive response of the organs arising from daily dosage of the extract or its metabolites within their body. Related: The Persian Shield plant is also in the Acanthaceae family. The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. PubMed Central There may be some problems if the air is too dry in winter. DOI: https://doi.org/10.1089/ars.2007.1901. Filed in Biochemistry Project Topics, Current Projects by TMLT Editorials on September 22, 2020. Joseph, H., Gleye, J., Moulis, C., Mensah, L. J., Roussakis, C., and Gratas, C. Justicidin B, a cytotoxic principle from Justicia pectoralis. 2013;1:38898. Corroborating with the results of the antioxidant system and weight of the liver, continuous exposure to higher dose (1200mg/kg) of JCEE could result in hepatic damage. It is also composed of vitamins and minerals good for heart health. Rats were further observed for extended hours of 48h to see if mortality would occur. Having discussed the nutritional benefits of ewe eje, i shall now take you through the various health benefits of justicia carnea leaves, and roots. One of the numerous nutritional benefits of justicia carnea leaves is in the possession of various forms of the B vitamins such as Vitamin B1, B2, B6, B9, and B12. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. Ewe eje improves the production of white blood cells and other antibodies, all which are essential for strengthening immunity. https://doi.org/10.4314/njps.v19i1.32627. Due to the local availability, easy access and relatively low cost, medicinal plants are gaining attentions in health care programmes. Acute toxicity was determined in two phases using Lorke method. The plant is transplanted in the spring. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. 32 years old (Greco et al., 1974), long-term treatment side effects are becoming more critical. This plant is somewhat drought-tolerant once established but looks best with regular watering during periods of extended dry weather. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. The indistinguishable differences of total protein in the liver and kidney of rats treated with ethanol extract of J. carnea could indicate that the plant extract did not alter protein synthetic function of the organs. Google Scholar. The plume flowers grow atop a crown of foliage in large dense clusters. This claim by traditional healers with regard to the efficacy of justicia carnea in the treatment diabetes have been researched on and it was found to be true. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. 2018;2018:5762368. The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. Uses, Benefits, Cures, Side Effects, Nutrients in Justicia Betonica. Also observed is a distortion in the walls of the blood vessels (red arrow), pyknotic hepatocytes and signs of inflammation (red arrow), Photomicrographs of kidney sections stained with Haematoxylin and Eosin (Mag. The animals were allowed free access to rat chow and water ad libitum. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. It also can be used in combination with other vegetables such as the Efinrin (scent leaves), ugwu etc. The genus Justicia named after the 18th-century Scottish botanist James Justice is a flowering plant in the family Acanthaceae. Each of the rats received 1500, 2900 and 5000mg/kg body weight of JCEE respectively and examined within 24h for manifestation of toxicity. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. There are several scientific studies which show that the methanolic leaf extract of Justicia carnea protects the liver from toxic effect of carbon tetrachloride harmful effect on the live integrity and functions. It can be used to manage diabetes consition properly. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . This study investigated the in-vitro antioxidant activity of ethanol leaf extract of Justicia carnea and its effect on antioxidant status of alloxan-induced diabetic albino rats. Keep the soil moist, but not waterlogged. Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. The very tropical looking Brazilian plume with its bright inflorescence is definitely a unique addition to gardens. Fertility leaves: Benefits and side effects, Guava Leaf Tea: Health Benefits of Guava Leaves, Coriander seeds: 18 benefits Coriandrum sativum fruits and seeds, Rapini: Nutritional facts, benefits, side effects and care. Clin Phytosci 2019; 5:9. https://doi.org/10.1186/s40816-019-0104-4. Infertility after therapy, in particular, imposes a significant mental strain on young patients. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. Once the roots have established, adjust watering to three to five days apart. Joseph, H., Gleye, J., Moulis, C., Fouraste, I., and Stanislas, E. O-Methoxylated C-glycosylflavones from Justicia pectoralis. Ewe eje is good for the liver. Aside boosting blood production in normal persons, justicia carnea leaves also reverses anemic conditions. Water your plants deeply during growth periods, allowing the soil to dry . 2003;66:1499503. Data were analyzed using one-way analysis of variance (ANOVA) using Statistical Product and Service Solutions (SPSS) version 17.0 and results were expressed as meanSEM. 2016;4(1):5360. The LD50 of extract was greater than 5000mg/kg body weight. The flowering Justicia plant is a perennial native to the Atlantic Forest eco-regions in eastern Brazil. They are also needed in strong bone formation, and in cellular and neuronal functions. Rats were routinely observed for signs of toxicity. In phase I, rats were randomized into 3 groups of 3 rats per group. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. Justicia carnea (belonging to Acanthaceae family) is a flowering plant consisting ~600 species that are widely distributed in the tropics and subtropics [7]. Justicia carnea does not cause miscarriage or congenital birth defects. This may be because of its hepatoprotective activity. The blood stimulating effects could be due to the presence of dietary bioactive constituents that stimulate activities of haematopoietic cells and stabilization of blood in circulation [21]. You can add milk or honey for taste before drinking. Whether added to garden beds or pots, the justicia (plant) adds a colorful tropical touch and are easy to grow. 1978;90:819. The Justicia carnea leaves are rich in B-vitamins. Tissues were processed automatically using automatic tissue processor (Leica TP 1020) and allowed to pass through varying percentage of alcohol and absolute alcohol for the purpose of dehydration following dewaxing in Xylene for 15mins. statement and Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. 400). Despite the use of Justicia carnea and other reported scientific studies, there are no reports on its effects on the major organs of the body. Leal, L. K., Ferreira, A. Mr. K.O. While graded doses of J. carnea ethanol extract showed no significant difference in the liver and kidney GSH compared to the control, only rats that received 1200mg/kg body weight JCEE statistically decreased in the kidney. Ethnomedical study and iron content of some medicinal herbs used in traditional medicine in cote divoire for the treatment of anaemia. Inter J Biochem Cell Bio. The animals were randomly distributed into cages and allowed to acclimatize for 2 weeks in a well ventilated room under natural lighting condition. The presence of blood boosting nutrients such as iron, copper, zinc and vitamin C can help prevent iron-deficiency anaemia and other anemic conditions. https://doi.org/10.1016/j.jada.2008.06.430. Niger J Physiol Sci. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. Liver and kidney in all treated groups maintained similar activities of catalase (CAT) compared to the control. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). leaf inhibits interferon-γ secretion and has bacteriostatic activity against Acinetobacter baumannii and Klebsiella pneumoniae. Sample (or standard solution) (0.01ml) was mixed with diluted (1:4v/v distilled water) biuret reagent (100mM sodium hydroxide, 16mM sodium-potassium tartrate, 15mM potassium iodide and 6mM copper sulphate). This encourages better flowering and bushier and denser new growth. Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). https://doi.org/10.35841/biomedicalresearch.30-18-666. Stover PJ, Caudill MA. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. However, coadministration of both extracts exerts a synergistic effecton the . It is commonly referred to as blood root, blood booster, ewe eje in Yoruba, Ogwu obara in Igbo, and jacobinia in Brazil and south America.The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. https://doi.org/10.1016/j.jep.2005.06.013. The reference cuvette contained 2.95ml buffer, 0.03ml of substrate (epinephrine) and 0.02ml of water. Article Organic extract of Justicia pectoralis Jacq. Too much fertilizer is damaging for your plant. Terms and Conditions, Vitamin B aids in the formation of red blood cells and helps to build tissues. Phytother Res 2011;25(3):444-450. When the Jacobinians are newly planted, water them daily for a few weeks. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. Cite this article. View abstract. 2). Rather it can assist with improveing liver function such as detoxification. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. When it comes to fertilizing, an NPK balance of 5-10-5 will work well, encouraging blooming and strong growth. 4. This information may not fit your specific health circumstances. Histopathological examinations of sections of the liver collected from the 4 The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. Paradoxically, oxidation of GSH has been reported to occur when GSH interact with metal ions thereby generating superoxide anions from the transfer of electrons from the metal ions to molecular oxygen [32]. It creates the perfect environment for aphids and dried sod. . Too much sun can scorch the leaves, and too little will result in fewer flowers. View abstract. Authors KOK and ESA performed the statistical analysis and managed the analyses of study. In-vivo studies have revealed that radicals produced from these dietary antioxidants are constantly regenerated back to their active form by GSH in the ascorbate glutathione cycle.
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