Be sure to read this information carefully each time. * Sex and gender exist on spectrums. Youll receive Prolia doses from a healthcare professional. If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. Talk with them about your health and any concerns you have about Prolia and its effects. What osteoporosis medications are there, and what side effects do they have? Prolia and Forteo are both used to treat osteoporosis. Do not use denosumab if you are pregnant. Studies of Prolia didnt report weight gain as a side effect of the drug. And some of these side effects are more common with certain uses of Prolia. We do not endorse non-Cleveland Clinic products or services. Prolia may be used off-label for RA, if you have a high risk for bone fractures. Prolia may lower the calcium levels in your blood. Fracture in the spine after stopping Prolia treatment. Whats the Connection Between Estrogen and Osteoporosis? But its not clear whether this side effect occurred in clinical studies. Bring someone with you to your appointment if doing so will help you feel more comfortable. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. Your doctor can also advise you on symptoms of low calcium to look for. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. Prolia is an injection prescribed for certain adults with osteoporosis, which Some rare side effects of Prolia can be serious and need medical attention. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Prolia can cause many serious side effects. Stopping Prolia doesnt cause withdrawal symptoms. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. WebMost people can get adequate calcium through their diet if they make an effort. Women Instead, it belongs to a different group of medications called biologics. Heres a sample meal plan thats packed with nutritious foods just for. All subjects in the clinical trials of Prolia received 800mg of calcium and For more information, you can refer to the drugs prescribing information. Call your doctor for medical advice about side effects. Talk with your doctor about the risks of using this drug during pregnancy. You may want to know how Prolia compares to the medication Tymlos. Do not treat yourself. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. Learn how to increase or maintain bone density here. Prolia improves bone mass and increases bone mineral density. The drug may increase the risk of pregnancy loss. * Sex and gender exist on spectrums. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. Some items may interact with your medicine. Ask your doctor about the pros and cons of using Prolia. The list below may not include all possible serious side effects of the drug. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use of the term male in this article refers to sex assigned at birth. You should receive your missed injection as soon as possible. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. Visit your doctor or health care professional for regular checks on your progress. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. Usually, but it depends. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. But its believed that these side effects are rare. Prolia is injected under the skin. Courtney Sullivan, Certified Yoga Instructor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Also, hair loss may be related to other medications you take or health conditions you have. You may report side effects to FDA at 1-800-FDA-1088. But this isnt the case with Prolia. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Continue reading, Prolia (denosumab) does increase bone density. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. If you have a low calcium level, you should not take Prolia. And you should continue using birth control for at least 5 months after stopping Prolia. If you have bothersome or severe side effects or other problems while taking Prolia and need to stop the medication, your doctor will monitor your bone mineral density. Prolia has active ingredients of denosumab. You can use the study as a second opinion to make health care decisions. With bone loss, your body loses old bone tissue faster than it makes new bone tissue. Prolia also has other uses, which are described in the next section below. Every 6 months youll get another dose of Prolia. Your doctor or health care professional may order blood tests and other tests to see how you are doing. This information is intended only for U.S. healthcare professionals. Some people may have an allergic reaction to Prolia. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture. You are encouraged to report negative side effects of prescription drugs to the FDA. RA is an autoimmune condition in which your immune system attacks your joints. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). Do not reuse a needle or syringe. Tell your doctor about all other medicines you use. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Theyll discuss with you other treatments to help prevent bone loss. Yes, if recommended by your doctor, you can stop taking Prolia. Its possible that some of Prolias side effects may be long term, but theyre rare. Theyll need to confirm that you arent pregnant. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. You should not breastfeed while using this medicine. This is called hypocalcemia. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. If you want to stop taking Prolia, tell your doctor. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. If youd like to learn more about Prolia, talk with your doctor or pharmacist. Some people may have dental or jaw-related issues with Prolia use. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Youll get Prolia injections from a healthcare professional once every 6 months. Prolia comes as a solution thats given as an injection under your skin. Cleveland Clinic is a non-profit academic medical center. But doing so can cause more bone breakdown and increase your risk for bone fractures. Copyright 1996-2023 Cerner Multum, Inc. Doing so will help you avoid the risk for a low calcium level during treatment. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. These factors include what your insurance plan covers. Learn about the highest quality calcium supplements here. If you develop serious side effects while taking Prolia, call your doctor right away. Tell your doctor if you become pregnant. Are there lifestyle changes that can help my osteoporosis. To learn more about these two drugs, check out this drug article. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. To learn how Prolia and Tymlos are alike and different, see this comparison. Call your doctor or health care professional if you are unable to keep an appointment. 2023 Healthline Media UK Ltd, Brighton, UK. But if they become bothersome, talk with your doctor or pharmacist. They can also happen if you have certain conditions or if you take certain medications. Do not stop using this medicine without first talking to your doctor. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. Prolia is also available in a biosimilar form. So treatment with the drug requires you to take daily calcium and vitamin D supplements. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. They may also have you see your dentist. If your Prolia treatment is stopped, talk to your doctor about other medicine that But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. As mentioned above, Prolia contains the active drug denosumab. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. Do not use denosumab if you are pregnant. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. Adults over age 50 should not exceed 2,000 mg total per day. You can learn more about how we ensure our content is accurate and current by reading our. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. All rights reserved. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If you are pregnant, you should not take Prolia. Prolia can also cause bones to not form correctly and reduced growth in a fetus. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Let your doctor know if you have questions about which drug is recommended for you. generic drugs) are not considered. Your side effects from Prolia may also vary depending on your gender. It could harm the unborn baby or cause birth defects. If your dizziness doesnt go away or becomes severe, talk with your doctor. But its not clear how often this side effect occurred in clinical trials. have happened in people who take Prolia. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). WebYou should take calcium and vitamin D as your doctor tells you to while you receive Biosimilars usually cost less than brand-name drugs. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. Do not stop, skip or delay taking Prolia without first talking with your doctor. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. Prolia is meant to be used in combination with calcium and vitamin D supplements. They might also recommend physical therapy, massage therapy, or using a heating pad. Prolia may lower the level of calcium in your blood. Your doctor can give you more information about the risks and benefits and how Reclast compares with Prolia. While you are using Prolia, you should not receive Xgeva, another brand of denosumab. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. if you are taking medicine that lower your blood calcium levels. Drug interactions are reported among people who take Prolia and Calcium. We study millions of patients and 5,000 more each day. Follow your doctor's instructions. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Women going through menopause have a higher risk of developing osteoporosis. Now i'm wondering if i shouldn't take K2. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Kidney problems. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. These side effects may be temporary, lasting a few days or weeks. Prolia comes with a warning about a low level of calcium in the blood. Below are answers to some commonly asked questions about Prolia. There arent any studies that have compared these two drugs to each other. And be sure to let your doctor know about all the medications youre currently taking. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Serious skin infections may occur, but are uncommon Theyll do this with certain tests, such as a bone scan or ultrasound. What should be considered before taking Prolia? They can also suggest ways to relieve this side effect. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. (2021). Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. There arent any reported interactions between Prolia and alcohol. Its thought that hair loss could occur due to how Prolia affects your immune system. But hair loss has been reported by people who have taken Prolia since then. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. Use effective birth control while using this medicine and for at least 5 months after your last dose. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.). Talk with your doctor about which medication is right for you. For a basic overview of Prolia, including details about its uses, see this article. High cholesterol levels can be a side effect of Prolia. Check with your doctor if you have more questions about these drugs. We avoid using tertiary references. You may be interested in learning how Prolia compares to the medication Fosamax. Calcium supplements may help support bone and teeth health. If youve already gone through menopause, your risk for bone loss is increased. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. It is important for you to practice good mouth care during treatment with Prolia. If you have serious side effects from Prolia, call your doctor right away. Forteo is given as a self-injection once daily. Brush and floss your teeth regularly while receiving this medication. Is the ketogenic diet right for autoimmune conditions? Do any of yall know? Theyll also usually treat the hypocalcemia right away. The drug could cause your calcium level to drop too low. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. Call your doctor for medical advice about side effects. Musculoskeletal pain from Prolia is mild or manageable for most people. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. Some reports may have incomplete information. Web You will receive Prolia 1 time every 6 months. What should I know about Prolia vs. Evenity? What should I know about Prolia vs. Reclast? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. You may also want to do some research on your own. * Approximation only. The most common medications prescribed to lower cholesterol are statins. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Last medically reviewed on November 29, 2022. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. If youre concerned about tingling while using Prolia, talk with your doctor. If you receive Prolia, you should not receive XGEVA. For a detailed breakdown of Prolia versus Xgeva, check out this article. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. Your doctor can help you decide which drug is better for your needs. These supplements help to prevent a low calcium level while youre taking Prolia. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. You may report side effects to FDA at 1-800-FDA-1088. Our website services, content, and products are for informational purposes only. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. Generic name: denosumab (Prolia) [den-OH-sue-mab] Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct Its recommended that calcium and vitamin D supplements be taken with Prolia. Talk to your health care professional or pharmacist for more information. Your risk for some health conditions increases when you are postmenopausal. But certain choices and habits accelerate the process. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? You might be interested in seeing how Prolia and the drug Boniva compare. Results may vary. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. They may give you tips on managing a body weight thats healthy for you. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Tell your doctor right away if you become pregnant while taking Prolia. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. Prolia also carries a warning about hypocalcemia, which is a low level of What is the most important information I should know about Prolia? Discuss the foods you eat and the vitamins you take with your health care professional. But it can increase your risk of serious health problems, such as heart attack. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. Thyroid or parathyroid surgery. Available for Android and iOS devices. Weakness and tingling can also occur. It is important not to miss your dose. A solid routine can help to strengthen your muscles and bones, which helps to lower your, If you have osteoporosis, diet plays a vital role in managing your condition. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. Prolia contains the active ingredient denosumab. Q: Does AlgaePlus Increase Bone Mass? If you miss a dose of Prolia, you should receive your injection as soon as you can. Your doctor will explain how Prolia will be given to you. But nausea may be a symptom of side effects such as vertigo or constipation. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. You should also talk with them if you have any serious side effects during Prolia treatment. See additional information. An allergic reaction is possible after using Prolia. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin No, weight gain wasnt reported as a side effect of Prolia in clinical trials. This makes your bones weak and increases your risk for bone fractures or breaks. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. If you have low blood calcium, it may get worse during treatment. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. What do I need to be aware of if I need a tooth extraction while Im using Prolia? WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. (Hint: it's not just. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. You may wonder how Prolia compares to the medication Zometa. Different individuals may respond to medication in different ways. If youre concerned about weight gain with Prolia, talk with your doctor. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Osteoporosis medications and medication-related osteonecrosis of the jaw. Below, we answer some common questions about taking Prolia. Be sure to talk with your doctor about which medication is right for you. Common You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. And they want you to get the best care possible. Dosage of drugs is not considered in the study. For Prolia, talk to your pediatrician regarding the use of this medicine in children. Drug class: Miscellaneous bone resorption inhibitors. (A low blood calcium level is a possible side effect of Prolia.). And if you have osteoporosis, falling could increase your risk of fractures. Youll receive Prolia doses from a healthcare professional. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). Brush and floss your teeth regularly. But if youre planning to have surgery, you may need to take a break Talk with your doctor about your health history and discuss your risks with Prolia treatment. This medicine may cause jaw bone problems (osteonecrosis). They can treat the infection as needed. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Call your doctor for medical advice about side effects. And ask your doctor about which drug is right for your condition. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. Use of the terms female and male in this article refers to sex assigned at birth. Please see Prolia full These types of medications come in forms that are taken by mouth and forms that are given by injection. (Biologic medications are made from living organisms.). Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Patients should not stop Prolia treatment without first consulting your Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. They may help you identify other possible causes or suggest ways to help manage hair loss. reintroduction of field margins and hedgerows disadvantages, browsers require user interaction before they will play audio,
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